I suppose I should build a case and then present the conclusion, but I'll keep this simple: No, you can't reconcile drug use (such as marijuana) with Christianity.
Does that mean a "true Christian" will never smoke weed? No, we all sin, and we all are tempted in different ways. Drugs have never been a temptation for me personally, but they certainly are for many other people. It's one thing to stumble into sin, and something far more shameful to excuse sin and try and argue with what the Bible clearly teaches.
1 Corinthians 10:13 - There hath no temptation taken you but such as is common to man: but God is faithful, who will not suffer you to be tempted above that ye are able; but will with the temptation also make a way to escape, that ye may be able to bear it.
The Bible talks many times about being sober and warning against drunkenness.
In Romans 13 we read, "The night is far spent, the day is at hand: let us therefore cast off the works of darkness, and let us put on the armour of light. Let us walk honestly, as in the day; not in rioting and drunkenness, not in chambering and wantonness, not in strife and envying. But put ye on the Lord Jesus Christ, and make not provision for the flesh, to fulfil the lusts thereof." This verse contrasts several things, such as drunkenness, with the positive thing: put ye on the Lord Jesus Christ... Walking with Christ cannot be reconciled with drunkenness, they are mutually exclusive. Ephesians 5:18 is clear on this as well.
The problem with drugs, and the key difference between drugs and alcohol, is that drugs are used for the express purpose of leaving sobriety. So while it is understandable that any Christian will stumble into sin, we must not excuse our favorite sin by pretending the Bible allows it. And there is no practical difference between drunkenness and "getting high".
Titus 1:7-8 - For a bishop must be blameless, as the steward of God; not selfwilled, not soon angry, not given to wine, no striker, not given to filthy lucre; But a lover of hospitality, a lover of good men, sober, just, holy, temperate.